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7 total results found

First-Order Elimination Kinetics

Math in Clinical Pharmacology Math in Pharmacokinetics

For most drugs, the amount of drug eliminated from the body during any time interval is proportional to the total amount of drug present in the body. In pharmacokinetic terms, this is called first-order elimination and is described by the equation Separa...

Type
Article
Status
Trial
Date
2025-11

Leibniz's Notation

Math in Biometrics Mathematical Analysis

Who is Leibniz Gottfried Wilhelm Leibniz (1646 - 1716) was a 17th century German mathematician. He’s often credited with developing many of the main principles of differential and integral calculus, and is primarily recognized for what we now call Leibniz’s no...

Type
Article
Status
Trial
Date
2025-11

Trial Users List

Community Trial Users

IoC

Type
Article
Status
Final
Date
2026-01

Authors List

Community Authors

IoC C Colin WANG, Ph.D School of Mathematical Sciences, University of Lancaster Institution of Oncology, Chinese Academcy of Medical Science Data Science, Luye Pharma F ...

Type
Article
Status
Final
Date
2026-01

Modified Fibonacci Sequence

Dose Escalation Math in Dose Escalation

Fibonacci Sequence The classic Fibonacci sequence is defined by the linear recurrence equation: Which goes like 1, 1, 2, 3, 5, 8, 13, 21, 34, 55, 89, ... In another words, the next number in the sequence is equal to the sum of its two predecessors. The r...

Type
Article
Status
Final
Date
2026-01

A Review of Clinical Pharmacology Considerations in Antibody-drug Conjugates Approved by the US Food and Drug Administration Between 2000 and 2025

Fun Fact ADC

by Seoyoung Koo, Chae Yeon Kim, Jeong-hyeon Lim, Eunyoung Lee, In Young Kim, Young G. Shin, and Hanlim Moon Abstract Antibody-drug conjugates (ADCs) represent a promising class of anticancer therapies with rapidly expanding development. However, regulatory app...

Type
Article
Status
Final
Date
2025-12

Contributors List

Community Contributors

IoC E Eric ZHANG, Ph.D, MBA School of Mathematics, Tsinghua University Data Science, Livzon Pharma J Junxian Zhao Clinical Development, Luye Pharma ...

Type
Article
Status
Final
Date
2026-01